Integron activity accelerates the evolution of antibiotic resistance | eLife

Antibiotic resistance – the ability of harmful bacteria to survive treatment by antibiotics – is a growing threat. It is making it harder to treat life-threatening infections, including tuberculosis, MRSA, and gonorrhoea – and increasing the risks of even minor surgery. 

In order to solve antibiotic resistance, one thing researchers first need to understand is how to stop resistance from happening to begin with. A recent study conducted at the University of Oxford has helped increase that understanding by showing bacteria can cleverly rearrange their genetics in order to evade the effects of an antibiotic.

Bacteria have multiple ways of evolving resistance. They can mutate to prevent antibiotics from targeting them, which can be done by modifying the proteins within the cell where antibiotics act. They can also acquire genes that help them produce antibiotic-destroying molecules, called enzymes.

https://elifesciences.org/articles/62474


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